Season 22 is a season of Greeny Phatom. The first episode of the season was The Ant Humans and the Spastic Mink (known as Minerva Mink Visits 123 Greeny Phatom in British airings), which featured the debut of the show's first permanent crossover character, Minerva Mink. The second episode was The Continued Adventures of the Beanson Gang. The third episode was We Are Obviously Not Number One.

More new writers join the team, including (but not limited to): Larry Charles, Larry David, and Bryan Gordon.

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